| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5211390 | Reactive and Functional Polymers | 2007 | 7 Pages |
Abstract
Synthesis of pH-responsive PEGylated nanogels platinum nanoparticles (PtNPs: <2Â nm) was successfully carried out through the reduction of K2PtCl6 within the PEGylated nanogels constructed from cross-linked poly[2-(N,N-diethylamino)ethyl methacrylate] (PDEAMA) core and tethered PEG chains. The resulting PEGylated nanogels containing PtNPs showed significant catalytic activity for reactive oxygen species (ROS) in response to skin-environmental pH (acid), whereas the almost no catalytic activity for ROS was observed at physiological pH due to the volume phase transition of the PDEAMA gel core. Thus, pH-responsive and PEGylated nanogel containing PtNPs can be utilized to the skin-specific ROS-scavengers for the skin aging.
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Authors
Motoi Oishi, Naoki Miyagawa, Takeshi Sakura, Yukio Nagasaki,