| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5211775 | Reactive and Functional Polymers | 2006 | 4 Pages |
Abstract
An efficient poly(ethylene glycol) (PEG)-supported liquid-phase parallel approach to di(aryloxyacetyl)thiosemicarbazides is described. PEG-bound phenol reacted with chloroacetic acid to afford PEG-bound phenyloxyacetic acid, which was readily converted into corresponding phenyloxyacetyl chloride. Subsequent nucleophilic substitution with ammonium thiocyanate followed by addition of aryloxyacetic acid hydrazides gave PEG-bound di(aryloxyacetyl)thiosemi-carbazides, which were easily cleaved to give the resulting library of 1-aryloxyacetyl-4-(4â²-methoxylcarbonylphenyloxyacetyl)thiosemicarbazides in good to high yield and high purity.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Junke Wang, Xicun Wang, Zheng Li, Yingxiao Zong,