| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5211904 | Tetrahedron | 2017 | 7 Pages |
Abstract
A facile and practical [3+2] cycloaddition/ring contraction for the construction of structurally diverse CF2H-containing spirocyclopropyloxindoles was developed. Starting from isatin-derived 3-ylideneoxindoles and in situ generated CF2HCHN2, the desired products were obtained in good to excellent results (up to 99% yield and >99:1 trans/cis) in the absence of metal catalyst. The potential application of the protocol was also demonstrated by the synthesis of the CF2H-substituted analog of HIV-1 NNRTI inhibitor.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wen-Yong Han, Jia Zhao, Jian-Shu Wang, Bao-Dong Cui, Nan-Wei Wan, Yong-Zheng Chen,