Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5211918 | Tetrahedron | 2017 | 6 Pages |
Abstract
An in situ activation of isatin-derived α,β-unsaturated acids 2 for the generation of isatin-derived α,β-unsaturated acyl azoliums II was described. The acyl azoliums II were successfully applied to undergo a formal [3 + 3] annulation with 1,3-dicarbonyl compounds to access functionalized 3,4â²-spirooxindole δ-lactones 4. A scale-up synthesis and an enantioselective variant of this protocol were also investigated. The stable and easily prepared acids 2 may be further utilized as promising versatile electrophilic 1,3-synthons for divergent synthesis of spirooxindoles.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Weiguo Zhang, Junyu Xu, Jing Cao, Chao Fang, Jindong Zhu, Tao Lu, Ding Du,