Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5211970 | Tetrahedron | 2017 | 6 Pages |
Abstract
The domino reactions of 2-fluoro benzensulfonyl acetonitrile and α-chloro oximes in the presence of Cs2CO3 in aprotic high boiling point solvents have been achieved to provide isoxazoleâfused 4H-1,4-benzothiazine-4,4-dioxides via an unprecedented transition metal-free one-pot addition/cyclization process. The tunable synthesis of either isoxozolo-1,4-benzothiazin-4-oxides or their precursor 5-aminoisoxazoles can be controlled depending on the solvent selection. The observed products were characterized by means of (IR, 1H, 13C NMR and HRMS) and physical methods.
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Authors
Ãzge Kavas, Cevher Altug,