Synthesis and utilization of optically active α-aminophosphonate derivatives by Kabachnik-Fields reaction

(S)-α-Phenylethylamine was used in the microwave-assisted Kabachnik-Fields condensation with paraformaldehyde and >P(O)H species, such as dialkyl phosphites, ethyl phenyl-H-phosphinate and diphenylphosphine oxide to provide optically active α-aminophosphonates, α-aminophosphinate and α-aminophosphine oxide, or using a two equivalent quantity of paraformaldehyde and (RO)2P(O)H or Ph2P(O)H, bis(phosphonomethyl)amines and bis(phosphinoylmethyl)amine, respectively. The bis(phosphinoylmethyl)amine served as a precursor for an optically active bidentate P-ligand in the synthesis of a chiral platinum complex.

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