| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5212121 | Tetrahedron | 2017 | 8 Pages |
Abstract
We have achieved a synthesis of multiply arylated pyridines by using a [4 + 2] cycloaddition of 2,4-diaryl-5-chloroxazoles and cinnamic acids as a key reaction. The resulting hydroxytriarylpyridines can be derivatized into triarylpyridines, tetraarylpyridines and pentaarylpyridines by sequential cross-couplings. This synthetic method allows for facile and rapid access to highly arylated pyridines with different aryl substituents.
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