| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5212139 | Tetrahedron | 2013 | 5 Pages |
Abstract
A novel five-component strategy involving commercially available diketene, primary amines, malononitrile and various benzaldehydes for the synthesis of densely functionalized 1,4-dihydropyridines in good yields was achieved. The reaction pathway involves a sequential ring-opening of diketene/enamine formation/Knoevenagel-condensation/Michael addition and 6-exo-tet cyclization, resulting in multiple bond-formation events including two C-C and three C-N bonds ultimately leading to the formation of the respective 1,4-dihydropyridines.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Atieh Rezvanian, Majid M. Heravi, Zahra Shaabani, Mahmood Tajbakhsh,