| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5212260 | Tetrahedron | 2017 | 9 Pages |
Abstract
The aldol reaction of N-heterocyclic carbaldehydes with furan-2-ones has been investigated. Very mild and metal-free reaction conditions have been applied. The substitution pattern of the product was found to be controlled by the aldehyde. A detailed investigation of the reactivity has been performed and the surprising regio- and diastereoselectivity has been elucidated with the help of 2D-NMR techniques. Here, we report on a convenient way to N-donor functionalized lactones, which had scarcely been examined before.
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