| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5212264 | Tetrahedron | 2017 | 7 Pages |
Abstract
N-Heterocyclic carbenes (NHCs) have been employed as highly efficient organocatalysts for fluorinated silyl-Reformatsky reaction of carbonyl compounds. In the presence of 5-10 mol % NHC A, various aldehydes and 2,2,2-trifluoroacetophenone reacted with difluoro (trimethylsilyl) acetate to produce β-hydroxy gem-difluoro esters in 20-96% yields.
Graphical abstractN-heterocyclic carbene-catalyzed fluorinated silyl-Reformatsky reaction of aldehydes and difluoro (trimethylsilyl) acetate.Download high-res image (138KB)Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ying Wang, Fen Xing, Cheng-Zhi Gu, Wen-Juan Li, Lin He, Bin Dai, Guang-Fen Du,