Article ID Journal Published Year Pages File Type
5212274 Tetrahedron 2017 8 Pages PDF
Abstract

Flow chemistry enables the preparation of bis(indolyl)methanes from various indoles and structurally divergent aldehydes using Sc(OTf)3 catalysis. The reaction is regioselective for C-3 functionalization of the indoles, occurring over short reaction times allowing for rapid investigation of scope with straightforward work up facilitating product isolation.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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