Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5212330 | Tetrahedron | 2017 | 9 Pages |
Abstract
A highly concise one-pot method towards biologically pertinent compounds having a [6-5-6] tricyclic framework has been established. The multicomponent reaction utilizes a tandem, double Diels-Alder cycloaddition followed by a Nazarov reaction to furnish the [6-5-6] backbone. This method produces three fused rings evolving from the construction of five new carbon-carbon bonds, a quaternary carbon, and stereogenic centers in a one-pot reaction. The products are produced with excellent regio- and diastereocontrol.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Rachael A. Carmichael, Wesley A. Chalifoux,