Stereoselective synthesis of α,α-difluoro-β,γ-alkenyl ketones by free-radical reaction of iododifluoromethyl ketones with alkynes

A method for stereoselective synthesis of α,α-difluoro-γ-iodo-β,γ-alkenyl ketones via radical difluoroacetylation of iododifluoromethyl ketones with terminal and internal alkynes was reported. This methodology provides a straightforward access to 3,3-disubstitued allylic difluorides.

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