Suzuki-Miyaura cross-coupling reaction of aryl chlorides with aryl boronic acids catalyzed by a palladium dichloride adduct of N-diphenylphosphanyl-2-aminopyridine

•Compound 1 is a PdCl2 adduct of N-diphenylphosphanyl-2-aminopyridine.•Compound 1 can catalyze the reactions of aryl chlorides with aryl boronic acids.•This catalytic system is suitable for a wide scope of substrates.

One palladium dichloride adduct of a phosphine-pyridine ligand N-diphenylphosphanyl-2-aminopyridine (L1) [(L1)PdCl2] (1) has been prepared and structurally characterized. Compound 1 can be used as an effective catalyst for the Suzuki-Miyaura cross-coupling reactions of unreactive aryl chlorides with aryl boronic acids, and worked much better than its mono- or bidentate phosphine ligands. The reactions with a wide scope of substrates proceeded to give desired products in good to excellent yields.

Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (91 K)Download as PowerPoint slide