| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5212502 | Tetrahedron | 2017 | 5 Pages |
Abstract
An efficient double Michael addition of nitromethane to divinyl ketones was established in good to high yields (75-99%). A wide range of cyclohexanones were obtained with excellent diastereocontrol (up to >20:1 dr) and enantioinduction (91-99% ee) in a one-pot fashion. The involvement of basic additive significantly enhanced the reactivity of this cascade sequence.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yongqi Yao, Yingying Liu, Ling Ye, Feng Chen, Xinying Li, Zhigang Zhao, Xuefeng Li,