| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5212602 | Tetrahedron | 2017 | 8 Pages |
Abstract
The ruthenium(II)-catalyzed site-selective acylation of indolinic C−H bonds with ethyl glyoxalate is described. A cationic ruthenium catalyst in the presence of copper(II) acetate was found to be an optimal catalytic system for the construction of C7-indolinyl ketoesters. In this process, C−H addition reaction first takes place, and subsequent oxidation of alcohol intermediates occur in-situ. The formed C7−functionalized indolines can be a crucial array towards the construction of novel bioactive molecules.
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