Synthesis and structural studies of new asymmetric pyridyl-tetrazole ligands for supramolecular chemistry

The synthesis of asymmetric diester derivatives of pyridyl-tetrazole ligands was successfully undertaken. Five crystal structures are reported including three asymmetric diesters (one of which is a mixed methyl ethyl ester derivative), a dicarboxylic acid and a monosodium (dicarboxylic acid)(monoacid-carboxylate) dihydrate intermediate. The dicarboxylic acid assembles by an unusual and unexpected route with the primary assembly based on carboxylic…pyridine (COOH⋯N) synthons that form an unusual cyclic hydrogen bonded ring with the R22(17) motif. Assembly in hydrogen bonding motifs using ‘odd’ numbers of atoms is the exception rather than the rule.

Graphical abstractThe synthesis of asymmetric diester derivatives of pyridyl-tetrazole ligands was successfully undertaken. Five crystal structures are reported including a dicarboxylic acid where the primary assembly, based on carboxylic…pyridine (COOH⋯N) synthons, forms an unusual cyclic hydrogen bonded ring with the R22(17) motif.Figure optionsDownload full-size imageDownload high-quality image (114 K)Download as PowerPoint slide