| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5212683 | Tetrahedron | 2017 | 7 Pages |
Abstract
Copper-catalyzed radical methylation of 1,3-diketones with tert-butyl peroxybenzoate in air is described, providing a general pathway to α-methyl 1,3-diketones in moderate to good yields. This protocol has been scaled up to 50 g, and one of the synthesized products can be used in the synthesis of medicine, Rosuvastatin.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhi-Hao Zhou, Cheng-Kun Li, Shao-Fang Zhou, Adedamola Shoberu, Jian-Ping Zou,