| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5212801 | Tetrahedron | 2017 | 8 Pages |
Abstract
A three-step protocol toward 1,1,2-triarylethanes 1 starting with β-ketosulfones 2 is developed. A facile process is carried out for the (1) reduction of 2 with NaBH4, (2) BF3·OEt2-mediated Friedel-Crafts reactions of the resulting β-hydroxy sulfones 3, and (3) palladium-catalyzed desulfonylative cross-coupling of the corresponding 5 with aryl iodides 4 in the presence of t-BuOK under warming DMF in acceptable yields. A facile synthesis of CDP-840 (1v) has been studied.
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