Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5212820 | Tetrahedron | 2017 | 5 Pages |
Abstract
Non-volatile S-Alkyl-S-phenyl-2,3,4,5-tetramethylphenylsulfonium triflate or tetrafluoroborate salts have been used to alkylate alcohols in the presence of sodium hydride. This is a simple and efficient method for the synthesis of ethers from complex alcohols and an alternative to the usual O-alkylation methods. This method was especially important for the preparation of monofluoromethyl ethers of a wide range of alcohols. Some alkylated derivatives of the precursors of some bioactive compounds were also prepared using these reagents.
Graphical abstractS-Alkyl-S-diaryl sulfonium salts as suitable reagents for the synthesis of ethers.Download high-res image (88KB)Download full-size image
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Osvaldo S. Ascenso, EmÃlia P.T. Leitão, William Heggie, M. Rita Ventura, Christopher D. Maycock,