| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5212968 | Tetrahedron | 2016 | 6 Pages |
Abstract
The radical arylation of the phenolic side chain of tyrosine in peptides was investigated. Aryl radicals were generated from aryldiazonium salts using titanium(III) chloride as stoichiometric reductant. Due to the high selectivity with which 3-aryltyrosine derivatives were formed, this reaction type represents a new strategy for the direct functionalization of peptides.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Stefanie K. Fehler, Gerald Pratsch, Christiane Ãstreicher, Michael C.D. Fürst, Monika Pischetsrieder, Markus R. Heinrich,