Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5213104 | Tetrahedron | 2016 | 9 Pages |
Abstract
A concise total synthesis of dendrodolides A-D (1-4) has been accomplished in 10 steps from commercially available (R)-propylene oxide and 3-buten-1-ol as starting materials. The key steps involved in the synthesis are Jacobsen hydrolytic kinetic resolution, epoxide ring opening with 2-allyl-1, 3-dithiane, Yamaguchi esterification and ring-closing metathesis (RCM). In addition, a series of ester derivatives were prepared utilizing Yamaguchi esterification at the C-3 position of the dendrodolide core and screened for their efficacy against cancer cell lines.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
B. Poornima, A. Venkanna, B. Swetha, Karthik reddy Kamireddy, Bandi Siva, V.S. Phani Babu, Ramesh Ummanni, K. Suresh Babu,