Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5213135 | Tetrahedron | 2016 | 7 Pages |
Abstract
A mild and efficient palladium-catalyzed cross-coupling between fluorinated vinyl chloride and arylboronic acids is described. The use of ligand B successfully overcomes the strong electronic withdrawing of trifluoromethylated substrates and allows the efficient synthesis of a wide range of α and α,β-trifluoromethyl containing olefins. By using this method, the key intermediate for synthesis of Efavirenz can be obtained in a simple route. The efficient conversion of two freon molecules into useful α and α,β-trifluoromethyl containing olefins is a useful route in organic chemistry.
Graphical abstractDownload full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yang Li, Bo Zhao, Kun Dai, Dong-Huai Tu, Bo Wang, Yao-Yu Wang, Zhao-Tie Liu, Zhong-Wen Liu, Jian Lu,