| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5213166 | Tetrahedron | 2016 | 8 Pages |
Abstract
Recently, we reported a directed evolution method which enabled us to discover sequences of glycopeptides that bind with picomolar affinity to HIV antibody 2G12 and are of interest as HIV vaccine candidates. In this manuscript, we describe the syntheses of several of these large (â¼11-12Â kDa) glycopeptides by a combination of fast flow peptide synthesis and click chemistry. We also discuss the optimization of their attachment to carrier protein CRM197, affording antigenic and immunogenic conjugates ready for animal vaccination.
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Related Topics
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Organic Chemistry
Authors
Jennifer K. Bailey, Dung N. Nguyen, Satoru Horiya, Isaac J. Krauss,