| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5213211 | Tetrahedron | 2016 | 5 Pages |
Abstract
An efficient five-step synthesis of muricadienin-d2 has been successfully developed for the first time. A partially deuterated naturally occurring acetogenin analog has been obtained in 58% yield via the Ti-catalyzed cross-cyclomagnesiation reaction of the oxygen-containing 1,2-dienes and terminal aliphatic 1,2-dienes with EtMgBr. Incorporation of two deuteriums at positions 14 and 17 occurs during the D2O treatment of the in situ generated magnesacyclopentane.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vladimir A. D'yakonov, Regina A. Tuktarova, Svetlana R. Ishmukhametova, Usein M. Dzhemilev,