Article ID Journal Published Year Pages File Type
5213279 Tetrahedron 2016 7 Pages PDF
Abstract

Partially fluorinated triazole derivatives were synthesized through anodic fluorination of alkynes having arylthio group and following Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with benzyl azide. The other route toward the fluorinated triazoles, namely the anodic fluorination of triazole derivatives once prepared by advanced CuAAC of the alkyne and azide above was also investigated. It was shown that these two routes are mutually complementary methodology for the synthesis of new mono- and difluoromethyltriazole derivatives. Furthermore, Cu(I)-catalyzed isoxazole synthesis from fluorinated alkynes and imidoyl chloride was demonstrated.

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Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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