| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5213362 | Tetrahedron | 2016 | 5 Pages |
Abstract
4-Aryl-3,4-dihydrocoumarins are a class of valuable molecules demonstrating attractive pharmaceutical and biological properties. In this paper, we designed a new and facile approach to synthesis of 4-aryl-3,4-dihydrocoumarin derivatives by Brønsted acid catalyzed Friedel-Crafts alkylation and cycloaddition reaction. With this protocol, 15 examples of 4-aryl-3,4-dihydrocoumarins were successfully prepared with yields ranging from 82 to 99%.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Cheng Chen, Rui Zhang, Long Lin, Guang-Fu Yang, Qiong-You Wu,