| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5213377 | Tetrahedron | 2016 | 5 Pages |
An approach employing two enzymes-toluene dioxygenase and immobilized lipase B from Candida antarctica (N435)-was explored as a potential biocatalytic method for the coupling of chiral diols with siloxane species. Analysis of reaction mixtures using 1H NMR spectroscopy suggested that up to 66% consumption of the siloxane starting materials had occurred. Oligomeric species were observed and chiral products from the coupling of a cyclic diol with a siloxane molecule were isolated and characterized by MALDI-ToF MS and GPC.Immobilized lipases from Rhizomucor miehei and Thermomyces lanuginosus were also explored as potential catalysts for the coupling reactions, however, their use only returned starting material.
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