An efficient route to diverse 2H-pyrano[3,2-c]quinolin-5(6H)-ones via electrophilic cyclization reactions

Electrophilic cyclization of 4-((3-arylprop-2-yn-1-yl)oxy)quinolin-2(1H)-one derivatives with iodine leads to the formation of 2H-pyrano[3,2-c]quinolin-5(6H)-ones bearing an alkenyl iodide moiety in good to excellent yields under mild conditions. The resulting iodo-containing 2H-pyrano[3,2-c]quinolin-5(6H)-ones could be further elaborated via palladium-catalyzed cross-coupling reactions.

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