Three-component [3+2+1] cyclizations leading to densely functionalized benzo[4,5]thiazolo[1,2-a]pyrimidines

A facile method has been developed for the preparation of densely functionalized tricyclic fused pyrimidine derivatives by three-component [3+2+1] cyclization. Fairly good yields of the products (up to 88%), the ready availability of the low-cost starting materials, the catalyst-free and mild conditions are the main advantages of this method.

Graphical abstractA facile three-component [3+2+1] cyclization protocol for the preparation of densely functionalized tricyclic fused pyrimidine derivatives has been designed.Figure optionsDownload full-size imageDownload high-quality image (159 K)Download as PowerPoint slide