Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5213993 | Tetrahedron | 2016 | 5 Pages |
Abstract
Enantioselective syntheses of triptoquinone H and its C-5 epimer were accomplished for the first time in seven linear steps and 33% overall yield from aldehyde 6 and Wittig salt 5 via a key palladium-catalyzed asymmetric dearomative cyclization. The P-chiral biaryl monophosphorus ligand AntPhos was proved to be efficient for the asymmetric dearomative cyclization to provide the tricyclic compound 8 bearing a chiral all-carbon quaternary center in 85% ee and 87% yield.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhen Cao, Kang Du, Jianhui Liu, Wenjun Tang,