Iron-catalyzed C–C bond formation via cross dehydrative coupling reaction of N-heterocyclic aminols with electron rich arenes: facile access to C4-aryl-dihydroquinazolines

The direct coupling of sp3 C–OH bond of N-heterocyclic aminols with sp2 C–H bond of electron rich arenes have been achieved via iron catalyzed dehydrative cross coupling strategy. This novel protocol provides an efficient and straight forward route to access biologically important C4-aryl-3,4-dihydroquinazoline derivatives through the reaction of C4-hydroxy-3,4-dihydroquinazoline/aminol with phenol and aniline derivatives under mild reaction conditions.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide