Rh(II)-catalyzed intramolecular dearomatizing annulation of N-sulfonyl-1,2,3-triazoles: synthesis of polycyclic spiroindolines

An efficient approach for the synthesis of polycyclic spiroindolines has been developed by utilizing Rh(II)-catalyzed dearomatizing annulation of sulfonyl triazoles. An enantioselective variant of the process was also looked into briefly to achieve polycyclic spiroindolines in good yield with a promising 73.3: 26.7 enantiomeric ratio, demonstrating the potential for asymmetric catalysis.

Graphical abstractAn efficient approach for the synthesis of polycyclic spiroindolines has been developed by utilizing Rh(II) catalyzed dearomatizing annulation of sulfonyl triazoles. The corresponding cyclization products were obtained in up to 93% yield.Figure optionsDownload full-size imageDownload as PowerPoint slide