| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5214119 | Tetrahedron | 2015 | 7 Pages |
Abstract
A novel palladium-catalyzed double carbonylation approach toward the synthesis of 3,4-dihydroisoquinoline-1-carboxamides is reported. The method developed involves an initial palladium-catalyzed double carbonylation of an N-protected alkylamine aryliodide to afford an α-keto carboxamide intermediate, which on subsequent deprotection undergoes intramolecular imine formation to afford the benzo-azacyclic product.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Hisashi Masui, Natsumi Ishizawa, Shinichiro Fuse, Takashi Takahashi,