| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5214124 | Tetrahedron | 2015 | 7 Pages |
Abstract
The highly enantioselective trifluoropyruvate-ene reactions of chiral steroid side chain olefins were achieved by dicationic palladium complexes as chiral Lewis acid catalysts to give steroidal ene-products in high diastereoselectivity. The ene products exhibited remarkably high agonist activities for human osteocalcin even in low vitamin D receptor binding affinity for human vitamin D hormone receptor.
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Related Topics
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Organic Chemistry
Authors
Kumiko Fujita, Junpei Aida, Koichi Mikami,