| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5214317 | Tetrahedron | 2015 | 6 Pages |
Abstract
A practical and chemoselective method is described for the O-methylation of carboxylic acids. Dimethyl malonate, a low toxic and commercially available compound was found to be an effective methylating reagent for a variety of carboxylic acids affording methyl ester products in good to high yields and with excellent chemoselectivity, without the use of strong bases as additives. A mechanism involving the utilization of potassium bromide is tentatively proposed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jincheng Mao, Defu Liu, Yongming Li, Jinzhou Zhao, Guangwei Rong, Hong Yan, Guoqi Zhang,