Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5214320 | Tetrahedron | 2015 | 7 Pages |
Abstract
In this manuscript, we describe various approaches that we have examined towards the total synthesis of Cytospolide E. We initially attempted the RCM approach employing first and second generation Grubbs and Grubbs-Hoyeda catalysts resulting in the exclusive synthesis of the Z-isomer of Cytospolide E. With the Fürstner catalyst, the dimerization involving the less hindered olefin was the exclusive event. Alternative approach documented is a successful cross-metathesis leading to a seco-acid with the requisite E-configuration and undesired macrodiolide formation during the attempted Shiina's lactonization.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paresh M. Vadhadiya, Jeetendra K. Rout, C.V. Ramana,