| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5214386 | Tetrahedron | 2015 | 6 Pages |
Abstract
The paper presents an efficient and stereoselective method for constructing spirocyclohexane indane-1,3-diones. This method is based on a chiral squaramide-catalysed highly diastereo- and enantioselective cascade Michael/aldol reaction between γ-nitro ketones and 2-arylidene-1,3-indanedione that affords functionalised spirocyclohexane products in high chemical yields with the formation of three stereogenic centres (57–97%; up to >20:1 dr and 86% ee).
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Related Topics
Physical Sciences and Engineering
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