| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5214405 | Tetrahedron | 2015 | 7 Pages |
Abstract
A novel method for the Baeyer-Villiger oxidation of ketones has been developed and optimized. The transformation involves a transition metal-free activation of hydrogen peroxide under Payne epoxidation conditions. Reaction of a ketone with hydrogen peroxide in the presence of a nitrile under mildly basic reaction conditions leads to the corresponding ester. The transformation has been successfully applied to a range of ketones in moderate to excellent yields (30-91%) and good to excellent regioselectivities (7:1 to 20:1).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tyne D. Bradley, Andrei Dragan, Nicholas C.O. Tomkinson,