Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5214409 | Tetrahedron | 2015 | 7 Pages |
Abstract
Tosylhydrazine mediated conjugate reduction of 2-hydroxyl chalcones and sequential reductive coupling cyclization is described. This is an unprecedented protocol and an extremely efficient method for a one-pot domino synthesis of 2-arylchromans in good to excellent yields from commercially available, cheap starting materials. More importantly, the two-step reactions can be easily controlled to afford dihydrochalcones or 2-arylchromans by the mole amounts of tosylhydrazine. Furthermore, the operational simplicity of the process and the high functional group tolerance are remarkable.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xuyang Shang, Xiaomeng Zhou, Wei Zhang, Changfeng Wan, Junmin Chen,