Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5214572 | Tetrahedron | 2015 | 7 Pages |
Pyrrolophenanthridinone derivatives including the natural products were readily synthesized by samarium(II)-mediated reductive cyclization of aryl radical onto a benzene ring under mild reaction conditions. This methodology was applied to the concise synthesis of anhydrolycorinone, a natural pyrrolophenanthridinone and a precursor of hippadine and anhydrolycorine.
Graphical abstractDownload full-size imagePyrrolophenanthridinone derivatives including natural product were readily synthesized by samarium(II)-mediated reductive cyclization of aryl radical onto a benzene ring via a spirohexadienyl radical intermediate under mild reaction conditions. This methodology was applied to the concise synthesis of anhydrolycorinone, which can be transformed into hippadine and anhydrolycorine.