Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5214594 | Tetrahedron | 2015 | 15 Pages |
Abstract
A stereoselective formal total synthesis of the 20-membered marine macrolide Palmerolide A, a highly potent antitumor agent, is described. The key steps involved in this synthesis are reductive elimination, Sharpless asymmetric dihydroxylation, protecting group dependent ring-closing metathesis reaction, Sharpless asymmetric epoxidation, Takai olefination and macrolactonization via Heck coupling reaction.
Graphical abstractDownload full-size image
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Bighnanshu K. Jena, Debendra K. Mohapatra,