| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5214633 | Tetrahedron | 2015 | 7 Pages |
Abstract
A dihydropyridone-mediated approach to the morphine skeleton was investigated. The hexahydroisoquinoline 2 was synthesized in nine steps using N-acylpyridinium chemistry and dihydropyridone functionalization methods. This new approach should be useful in the design of more efficient syntheses of morphine and its derivatives.
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