| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5214640 | Tetrahedron | 2015 | 6 Pages |
Abstract
A simple method for the synthesis of inaccessible gem-dinitro derivatives of pyridine is described. A wide range of 2-halogencycloalka[b]pyridine-3,4-dicarbonitriles are produced by the three-component reaction (ketone, TCNE, hydrohalic acid), side-chain nitration of latter with 60% nitric acid in a solvent-free conditions leads to the formation of gem-dinitro derivatives with high selectivity and without disturbing of other reaction centers.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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