Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5214772 | Tetrahedron | 2015 | 5 Pages |
Abstract
A diterpene with a new skeleton, niphateolide A (1), was isolated from the marine sponge, Niphates olemda, as an inhibitor of the p53-Hdm2 interaction. Its structure was elucidated by NMR spectroscopy and its absolute configuration was established as 10R, 11R by ECD at the vacuum-ultraviolet region with a theoretical calculation. Compound 1 was observed as an inseparable stereoisomeric mixture at C-17 and an ECD analysis was subsequently performed by adopting a virtual equilibrium between the simplified two forms, 10R,11R,17R- and 10R,11R,17S-1a, in which the calculated ECD spectra were correctively integrated with the theoretically-derived internal and free energies.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hikaru Kato, Tatsuo Nehira, Koichi Matsuo, Tetsuro Kawabata, Yoshihiro Kobashigawa, Hiroshi Morioka, Fitje Losung, Remy E.P. Mangindaan, Nicole J. de Voogd, Hideyoshi Yokosawa, Sachiko Tsukamoto,