| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5214811 | Tetrahedron | 2015 | 9 Pages |
Abstract
We present an allylic polyfluoroarylation reaction with broad substrate scope and excellent functional group tolerance, using organozinc reagents under mild conditions. A catalytic amount of triphenylphosphine oxide efficiently promotes iodine-zinc exchange reaction between polyfluoroaryl iodide and dimethylzinc, and the resulting phosphine oxide-activated polyfluoroarylzinc undergoes substitution reaction with allylic halides to afford the corresponding polyfluoroarylated products.
Graphical abstractDownload high-res image (191KB)Download full-size image
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Daisuke Kurauchi, Keiichi Hirano, Hisano Kato, Tatsuo Saito, Kazunori Miyamoto, Masanobu Uchiyama,