Concise synthesis of (+)-subersic acid from (−)-Sclareol

A short and efficient synthesis of (+)-subersic acid in 6 steps with an overall yield of 8.6% from (−)-Sclareol was presented using Mitsunobu reaction and Claisen rearrangement as critical steps. This elegant protocol gave a convenient access to gram scales of (+)-subersic acid, which could be a precursor for its structural analogues and for further bioactivity researches.

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