Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5214912 | Tetrahedron | 2015 | 7 Pages |
Abstract
Novel chiral dendrimer-triamine-coordinated Gd complexes with polyaminoalcohol end groups were synthesized and shown to have longitudinal relaxivity (r1) values 5 times higher than that of clinically used Gd-DTPA. The affinities of Gd-4a and Gd-4b for bovine serum albumin (BSA), respectively, were estimated by a quartz crystal microbalance (QCM) measurement. The amino groups of the dendrimer were then conjugated with PEG. This conjugation with PEG strongly affected its ability to attenuate signals in T1-weighted MRI.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuka Miyake, Yu Kimura, Naomi Orito, Hirohiko Imai, Tetsuya Matsuda, Akio Toshimitsu, Teruyuki Kondo,