Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5214948 | Tetrahedron | 2015 | 8 Pages |
Abstract
Asymmetric Michael reactions of α-fluoro-β-ketoesters to nitroolefins have been achieved by using readily accessible primary-secondary diamines as the organocatalysts through enamine activation mode, affording the useful Michael adducts bearing chiral fluorinated quaternary carbon in good yields, with high diastereoselectivities and enantioselectivities (up to 87% yield, >20:1 d.r. and 99% ee).
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