Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5214949 | Tetrahedron | 2015 | 9 Pages |
Abstract
Herein, we report synthetic strategies towards a library of amphiphilic tetraphenyl porphyrins anchored to synthetic saccharides and lipid modalities. The carbohydrates and lipid functionalities are covalently linked to the model photosensitizer via a copper (I) catalyzed alkyne azide cycloaddition reaction or an oxypropyl linkage achieved by nucleophilic substitution chemistry. Varying substitutions of carbohydrates and lipids allows for potential fine tuning of solubility and photophysical characteristics important for imaging and treatment applications in photomedicine, specifically in photodynamic therapy.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Claire Moylan, Ayman M.K. Sweed, Yasser M. Shaker, Eoin M. Scanlan, Mathias O. Senge,